Dietary Supplements

A guide to dietary supplements and sports supplements: possible benefit, quality of evidence, studied doses, risks and fit for your personal needs.

The supplement industry turns over billions, but only a small part of the shelf is really backed by evidence. This section reviews vitamins, minerals and performance supplements one by one — what their physiological role is, who is really deficient, what the effective dose is compared with the marketing dose, and when a supplement does more harm than good.

In-depth articles for athletes

ArticleKey questions
MagnesiumWhat is known about sleep and cramps, and how do you read the dose on the label?
BerberineWhat has really been proven about weight and blood sugar, and what does a 2026 trial teach us?
CreatineWho does it help, do you need a loading phase, and what does the weight gain mean?
CaffeineHow do you tell apart research doses, safety limits and harm to sleep?
Whey proteinWhen is a powder useful, and how do you choose between product types?
Beta-alanineIn which efforts might it help, and why is tingling not a measure of effectiveness?

Three questions before choosing a supplement

  1. What is the goal? Filling a nutritional gap, treating a deficiency and improving performance are different uses. There is no single list of supplements that suits everyone.
  2. What exactly was tested? It is important to check the study population, the dose and the outcome that was measured, and not to settle for an explanation of the mechanism of action.
  3. Does it suit your personal situation? Take into account medications, underlying conditions, other products and the need for tests based on medical judgment.

The AIS framework for evaluating supplements emphasizes safety, evidence of effectiveness and compliance with the rules of sport. Even a useful supplement is only part of a nutrition and training plan. The AIS supplement framework.

Vitamins

Vitamin A · Vitamin B1 · Vitamin B6 · Vitamin B9 · Vitamin B12 · Vitamin C · Vitamin D · Vitamin E · Vitamin K · Choline

Minerals

Calcium · Magnesium · Potassium · Sodium · Iron · Zinc · Selenium · Iodine · Copper · Manganese · Phosphorus

Sports supplements and other substances

Creatine · Whey protein · Beta-alanine · Caffeine · Omega-3 · Turmeric and curcumin · Berberine · Insulin: information on a hormone and a drug, not a dietary supplement · Combining supplements into a stack

Frequently asked questions

Question: Which supplements are worth considering for sport? Answer: It depends on the goal. Creatine and caffeine have a substantial evidence base for certain uses, protein powder can fill a nutritional gap, and beta-alanine may suit certain efforts. Details and sources appear in the articles linked above.

Question: Can you take several supplements together? Answer: Every combination needs to be checked according to the ingredients, the amounts, medications and medical condition. Several products may contain the same ingredient and create a cumulative intake that goes unnoticed.

Question: Does a higher dose work better? Answer: Not necessarily. A distinction should be made between a studied dose, a safety limit and a personal target. Detailed examples appear in the articles on magnesium and caffeine.

Question: Is berberine a proven performance supplement? Answer: There is no basis for presenting it that way. The research deals mainly with metabolic markers in certain populations; you can’t infer from it a promise of improved performance in healthy athletes.

Beta-Alanine for Athletes

Beta-alanine may help with certain high-intensity efforts. A guide to its mechanism of action, how long to take it, studied doses, tingling and assessing the real-world benefit.

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Insulin

The hormone that runs the body's energy economy: how insulin works, what insulin resistance is, and which foods and compounds affect it.

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Calcium

Calcium: how much you really need, why absorption from food varies so much, why dietary calcium lowers kidney stone risk while a supplement may raise it, and the debate over calcium supplements and the heart.

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Choline

Choline: why most of the population consumes less than recommended, its role in fetal brain development and fatty liver, the story behind TMAO, and why eggs are the main source.

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Copper

Copper: its role in mobilizing iron and in connective tissue, why deficiency is usually caused by a zinc supplement, and why anemia that doesn't respond to iron calls for a copper test.

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Folic Acid (Vitamin B9 / Folate)

Folic acid: why supplementation must start before conception, the difference between folate, folic acid and 5-MTHF, why it masks B12 deficiency, and what MTHFR really means.

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Iodine

Iodine: its role in the thyroid gland, why Israel is an unusual case with high deficiency rates, why kelp is dangerous, and why pregnancy is the critical period.

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Iron Supplement

Iron supplements: which form is absorbed best (bisglycinate vs. sulfate), the right dose, why every-other-day dosing beats daily, and how to reduce constipation and nausea.

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Manganese

Manganese: its role in the enzyme MnSOD and in building bone, why dietary deficiency is very rare, who is at risk of buildup, and why a manganese supplement is almost never needed.

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Phosphorus

Phosphorus: its role in bone and ATP, why deficiency is almost nonexistent, and why phosphate additives in processed food are absorbed almost 100% and are a real problem.

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Potassium

Potassium: the ratio to sodium that determines blood pressure, why potassium supplements are restricted by law, who must be careful with salt substitutes, and what the good sources really are.

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Selenium

Selenium: its role in the thyroid and in glutathione peroxidase, why its safe range is especially narrow, what the SELECT trial found, and how many Brazil nuts is already too many.

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Sodium

Sodium: how much is really OK, why most sodium comes from processed food rather than the salt shaker, why sea salt and Himalayan salt are no solution, and when too little sodium is actually dangerous.

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Vitamin A (Retinol)

Vitamin A: the decisive difference between retinol and beta-carotene, why liver is off-limits in pregnancy, what happened to smokers in the CARET and ATBC trials, and how much you really need.

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Vitamin B1 (Thiamine)

Vitamin B1: its role in producing energy from carbohydrates, why its stores are especially small, what beriberi and Wernicke's syndrome are, and who is truly at risk.

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Vitamin B12 (Cobalamin)

Vitamin B12: why its absorption is more complicated than any other vitamin's, who is truly at risk, why folic acid masks deficiency, and why pills work like injections.

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Vitamin B6 (Pyridoxine)

Vitamin B6: its role in more than 100 enzymes and in producing neurotransmitters, and why long-term high doses cause neuropathy — the most important caveat in this category.

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Vitamin C (Ascorbic Acid)

How much vitamin C you need per day, which foods provide it, what it does for colds and iron absorption, and what the upper limit and the risks of supplements are.

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Vitamin E (Tocopherol)

Vitamin E: its role as the antioxidant of cell membranes, why the SELECT trial and meta-analyses pointed to harm at high doses, and the difference between the natural and synthetic forms.

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Vitamin K

Vitamin K: the difference between K1 and K2, food sources and exact amounts, recommended intake, why babies get a shot at birth, and the interaction with Coumadin.

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Curcumin Supplement

Curcumin supplements: the effective dose, what research shows about joint pain and inflammation, why absorption is low and what piperine does for it, and when a supplement beats the spice.

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Vitamin D

A scientific review of vitamin D: the 'sunshine vitamin' that actually works as a hormone, its critical importance for bone health, and its link to mood and depression.

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Zinc

A scientific review of zinc: the mineral critical for the immune system, skin health and hormonal balance in men and women.

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Caffeine for Athletes

Caffeine may improve performance, but dose and timing decide the benefit and the risk. A guide to daily intake, sleep, drinks, supplements and testing it in training.

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Magnesium for Athletes

Does magnesium help with sleep and muscle cramps? A review for athletes of the quality of the evidence, the differences between supplement forms, elemental magnesium and safety.

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Omega-3

A scientific review of omega-3 fatty acids: their critical importance for heart and brain health, the differences between EPA and DHA, and how to choose a quality supplement.

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Whey Protein for Athletes

A guide to whey protein: how much protein you need, when a powder helps, how to choose between types, and the difference between lactose intolerance and a milk allergy.

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Creatine for Athletes

A guide to creatine monohydrate: who it helps, loading vs. daily dosing, weight gain, kidney function, and telling evidence apart from promises.

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